xHMMER3x2: Utilizing HMMER3’s speed and HMMER2’s sensitivity and specificity in the glocal alignment mode for improved large-scale protein domain annotation

BACKGROUND: While the local-mode HMMER3 is notable for its massive speed improvement, the slower glocal-mode HMMER2 is more exact for domain annotation by enforcing full domain-to-sequence alignments. Since a unit of domain necessarily implies a unit of function, local-mode HMMER3 alone remains insu...

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Detalles Bibliográficos
Autores principales: Yap, Choon-Kong, Eisenhaber, Birgit, Eisenhaber, Frank, Wong, Wing-Cheong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126834/
https://www.ncbi.nlm.nih.gov/pubmed/27894340
http://dx.doi.org/10.1186/s13062-016-0163-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126834/
https://www.ncbi.nlm.nih.gov/pubmed/27894340
http://dx.doi.org/10.1186/s13062-016-0163-0

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