Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses

Griffithsin (GRFT), a lectin from Griffithsia species, inhibits human immunodeficiency virus-1 (HIV-1) replication at sub-nanomolar concentrations, with limited cellular toxicity. However, in vivo safety of GRFT is not fully understood, especially following parenteral administration. We first assess...

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Detalles Bibliográficos
Autores principales: Kouokam, Joseph Calvin, Lasnik, Amanda B., Palmer, Kenneth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127025/
https://www.ncbi.nlm.nih.gov/pubmed/27869695
http://dx.doi.org/10.3390/v8110311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127025/
https://www.ncbi.nlm.nih.gov/pubmed/27869695
http://dx.doi.org/10.3390/v8110311

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