Preparation of 6/8/11-Amino/Chloro-Oxoisoaporphine and Group-10 Metal Complexes and Evaluation of Their in Vitro and in Vivo Antitumor Activity

A series of group-10 metal complexes 1–14 of oxoisoaporphine derivatives were designed and synthesized. 1–14 were more selectively cytotoxic to Hep-G2 cells comparing with normal liver cells. In vitro cytotoxicity results showed that complexes 1–6, 7, 8, 10 and 11, especially 3, were telomerase inhi...

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Detalles Bibliográficos
Autores principales: Qin, Qi-Pin, Qin, Jiao-Lan, Meng, Ting, Yang, Gui-Ai, Wei, Zu-Zhuang, Liu, Yan-Cheng, Liang, Hong, Chen, Zhen-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127189/
https://www.ncbi.nlm.nih.gov/pubmed/27898051
http://dx.doi.org/10.1038/srep37644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127189/
https://www.ncbi.nlm.nih.gov/pubmed/27898051
http://dx.doi.org/10.1038/srep37644

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