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Chemokine Levels in the Penile Coronal Sulcus Correlate with HIV-1 Acquisition and Are Reduced by Male Circumcision in Rakai, Uganda

Individual susceptibility to HIV is heterogeneous, but the biological mechanisms explaining differences are incompletely understood. We hypothesized that penile inflammation may increase HIV susceptibility in men by recruiting permissive CD4 T cells, and that male circumcision may decrease HIV susce...

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Detalles Bibliográficos
Autores principales: Prodger, Jessica L., Gray, Ronald H., Shannon, Brett, Shahabi, Kamnoosh, Kong, Xiangrong, Grabowski, Kate, Kigozi, Godfrey, Nalugoda, Fred, Serwadda, David, Wawer, Maria J., Reynolds, Steven J., Liu, Cindy M., Tobian, Aaron A. R., Kaul, Rupert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127584/
https://www.ncbi.nlm.nih.gov/pubmed/27898732
http://dx.doi.org/10.1371/journal.ppat.1006025