SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks

Ruijs-Aalfs syndrome is a segmental progeroid syndrome resulting from mutations in the SPRTN gene. Cells derived from patients with SPRTN mutations elicit genomic instability and people afflicted with this syndrome developed hepatocellular carcinoma. Here we describe the molecular mechanism by which...

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Detalles Bibliográficos
Autores principales: Lopez-Mosqueda, Jaime, Maddi, Karthik, Prgomet, Stefan, Kalayil, Sissy, Marinovic-Terzic, Ivana, Terzic, Janos, Dikic, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127644/
https://www.ncbi.nlm.nih.gov/pubmed/27852435
http://dx.doi.org/10.7554/eLife.21491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127644/
https://www.ncbi.nlm.nih.gov/pubmed/27852435
http://dx.doi.org/10.7554/eLife.21491

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