Spatial intratumor heterogeneity of genetic, epigenetic alterations and temporal clonal evolution in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, but little is known about its spatial intratumor heterogeneity (ITH) and temporal clonal evolutionary processes. To address this, we performed multiregion whole-exome sequencing on 51 tumor regions from 13 ESCCs, and mu...

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Detalles Bibliográficos
Autores principales: Hao, Jia-Jie, Lin, De-Chen, Dinh, Huy Q., Mayakonda, Anand, Jiang, Yan-Yi, Chang, Chen, Jiang, Ye, Lu, Chen-Chen, Shi, Zhi-Zhou, Xu, Xin, Zhang, Yu, Cai, Yan, Wang, Jin-Wu, Zhan, Qi-Min, Wei, Wen-Qiang, Berman, Benjamin P., Wang, Ming-Rong, Koeffler, H. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127772/
https://www.ncbi.nlm.nih.gov/pubmed/27749841
http://dx.doi.org/10.1038/ng.3683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127772/
https://www.ncbi.nlm.nih.gov/pubmed/27749841
http://dx.doi.org/10.1038/ng.3683

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