Cargando…
IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity
Plasmacytoid dendritic cells (pDCs) have been shown to both mediate and prevent autoimmunity, and the regulation of their immunogenic versus tolerogenic functions remains incompletely understood. Here we demonstrate that, compared to other cells, pDCs are the major expressors of Indoleamine-2,3-diox...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127883/ https://www.ncbi.nlm.nih.gov/pubmed/27470005 http://dx.doi.org/10.1016/j.jaut.2016.07.004 |
_version_ | 1782470301754327040 |
---|---|
author | Lippens, Carla Duraes, Fernanda V. Dubrot, Juan Brighouse, Dale Lacroix, Mathilde Irla, Magali Aubry-Lachainaye, Jean-Pierre Reith, Walter Mandl, Judith N. Hugues, Stéphanie |
author_facet | Lippens, Carla Duraes, Fernanda V. Dubrot, Juan Brighouse, Dale Lacroix, Mathilde Irla, Magali Aubry-Lachainaye, Jean-Pierre Reith, Walter Mandl, Judith N. Hugues, Stéphanie |
author_sort | Lippens, Carla |
collection | PubMed |
description | Plasmacytoid dendritic cells (pDCs) have been shown to both mediate and prevent autoimmunity, and the regulation of their immunogenic versus tolerogenic functions remains incompletely understood. Here we demonstrate that, compared to other cells, pDCs are the major expressors of Indoleamine-2,3-dioxygenase (IDO) in steady-state lymph nodes (LNs). IDO expression by LN pDCs was closely dependent on MHCII-mediated, antigen-dependent, interactions with Treg. We further established that IDO production by pDCs was necessary to confer suppressive function to Tregs. During EAE development, IDO expression by pDCs was required for the generation of Tregs capable of dampening the priming of encephalitogenic T cell and disease severity. Thus, we describe a novel crosstalk between pDCs and Tregs: Tregs shape tolerogenic functions of pDCs prior to inflammation, such that pDCs in turn, promote Treg suppressive functions during autoimmunity. |
format | Online Article Text |
id | pubmed-5127883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-51278832016-12-06 IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity Lippens, Carla Duraes, Fernanda V. Dubrot, Juan Brighouse, Dale Lacroix, Mathilde Irla, Magali Aubry-Lachainaye, Jean-Pierre Reith, Walter Mandl, Judith N. Hugues, Stéphanie J Autoimmun Article Plasmacytoid dendritic cells (pDCs) have been shown to both mediate and prevent autoimmunity, and the regulation of their immunogenic versus tolerogenic functions remains incompletely understood. Here we demonstrate that, compared to other cells, pDCs are the major expressors of Indoleamine-2,3-dioxygenase (IDO) in steady-state lymph nodes (LNs). IDO expression by LN pDCs was closely dependent on MHCII-mediated, antigen-dependent, interactions with Treg. We further established that IDO production by pDCs was necessary to confer suppressive function to Tregs. During EAE development, IDO expression by pDCs was required for the generation of Tregs capable of dampening the priming of encephalitogenic T cell and disease severity. Thus, we describe a novel crosstalk between pDCs and Tregs: Tregs shape tolerogenic functions of pDCs prior to inflammation, such that pDCs in turn, promote Treg suppressive functions during autoimmunity. Academic Press 2016-12 /pmc/articles/PMC5127883/ /pubmed/27470005 http://dx.doi.org/10.1016/j.jaut.2016.07.004 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Lippens, Carla Duraes, Fernanda V. Dubrot, Juan Brighouse, Dale Lacroix, Mathilde Irla, Magali Aubry-Lachainaye, Jean-Pierre Reith, Walter Mandl, Judith N. Hugues, Stéphanie IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity |
title | IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity |
title_full | IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity |
title_fullStr | IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity |
title_full_unstemmed | IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity |
title_short | IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity |
title_sort | ido-orchestrated crosstalk between pdcs and tregs inhibits autoimmunity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127883/ https://www.ncbi.nlm.nih.gov/pubmed/27470005 http://dx.doi.org/10.1016/j.jaut.2016.07.004 |
work_keys_str_mv | AT lippenscarla idoorchestratedcrosstalkbetweenpdcsandtregsinhibitsautoimmunity AT duraesfernandav idoorchestratedcrosstalkbetweenpdcsandtregsinhibitsautoimmunity AT dubrotjuan idoorchestratedcrosstalkbetweenpdcsandtregsinhibitsautoimmunity AT brighousedale idoorchestratedcrosstalkbetweenpdcsandtregsinhibitsautoimmunity AT lacroixmathilde idoorchestratedcrosstalkbetweenpdcsandtregsinhibitsautoimmunity AT irlamagali idoorchestratedcrosstalkbetweenpdcsandtregsinhibitsautoimmunity AT aubrylachainayejeanpierre idoorchestratedcrosstalkbetweenpdcsandtregsinhibitsautoimmunity AT reithwalter idoorchestratedcrosstalkbetweenpdcsandtregsinhibitsautoimmunity AT mandljudithn idoorchestratedcrosstalkbetweenpdcsandtregsinhibitsautoimmunity AT huguesstephanie idoorchestratedcrosstalkbetweenpdcsandtregsinhibitsautoimmunity |