The complement system, neuronal injury, and cognitive function in horizontally-acquired HIV-infected youth

The complement system (C1q/C3) is a key mediator of synaptic pruning during normal development. HIV inappropriately induces C1q and C3 production in the brain, and reduces neuronal complement inhibition. HIV may thus alter neural connectivity in the developing brain by excessively targeting synapses...

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Detalles Bibliográficos
Autores principales: McGuire, Jennifer L., Gill, Alexander J., Douglas, Steven D., Kolson, Dennis L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127892/
https://www.ncbi.nlm.nih.gov/pubmed/27273074
http://dx.doi.org/10.1007/s13365-016-0460-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127892/
https://www.ncbi.nlm.nih.gov/pubmed/27273074
http://dx.doi.org/10.1007/s13365-016-0460-5

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