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The complement system, neuronal injury, and cognitive function in horizontally-acquired HIV-infected youth
The complement system (C1q/C3) is a key mediator of synaptic pruning during normal development. HIV inappropriately induces C1q and C3 production in the brain, and reduces neuronal complement inhibition. HIV may thus alter neural connectivity in the developing brain by excessively targeting synapses...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127892/ https://www.ncbi.nlm.nih.gov/pubmed/27273074 http://dx.doi.org/10.1007/s13365-016-0460-5 |