Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core

Parkinson’s disease is a neurological disease in which aggregated forms of the α-synuclein (α-syn) protein are found. We used high hydrostatic pressure (HHP) coupled with NMR spectroscopy to study the dissociation of α-syn fibril into monomers and evaluate their structural and dynamic properties. Di...

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Detalles Bibliográficos
Autores principales: de Oliveira, Guilherme A. P., Marques, Mayra de A., Cruzeiro-Silva, Carolina, Cordeiro, Yraima, Schuabb, Caroline, Moraes, Adolfo H., Winter, Roland, Oschkinat, Hartmut, Foguel, Debora, Freitas, Mônica S., Silva, Jerson L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128797/
https://www.ncbi.nlm.nih.gov/pubmed/27901101
http://dx.doi.org/10.1038/srep37990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128797/
https://www.ncbi.nlm.nih.gov/pubmed/27901101
http://dx.doi.org/10.1038/srep37990

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