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Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core
Parkinson’s disease is a neurological disease in which aggregated forms of the α-synuclein (α-syn) protein are found. We used high hydrostatic pressure (HHP) coupled with NMR spectroscopy to study the dissociation of α-syn fibril into monomers and evaluate their structural and dynamic properties. Di...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128797/ https://www.ncbi.nlm.nih.gov/pubmed/27901101 http://dx.doi.org/10.1038/srep37990 |