Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?

Safety pharmacology aims to predict rare side effects of new drugs. We explored whether rare pro-arrhythmic effects could be linked to the variability of the effects of these drugs on ion currents and whether taking into consideration this variability in computational models could help to better det...

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Detalles Bibliográficos
Autores principales: Le Guennec, Jean-Yves, Thireau, Jérôme, Ouillé, Aude, Roussel, Julien, Roy, Jérôme, Richard, Serge, Richard, Sylvain, Martel, Eric, Champéroux, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128803/
https://www.ncbi.nlm.nih.gov/pubmed/27901061
http://dx.doi.org/10.1038/srep37948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128803/
https://www.ncbi.nlm.nih.gov/pubmed/27901061
http://dx.doi.org/10.1038/srep37948

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