Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions

Scaffold proteins such as the multidomain protein CNK1 orchestrate the signalling network by integrating and controlling the underlying pathways. Using an optogenetic approach to stimulate CNK1 uncoupled from upstream effectors, we identified selective clusters of CNK1 that either stimulate RAF-MEK-...

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Detalles Bibliográficos
Autores principales: Fischer, Adrian, Warscheid, Bettina, Weber, Wilfried, Radziwill, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128868/
https://www.ncbi.nlm.nih.gov/pubmed/27901111
http://dx.doi.org/10.1038/srep38155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128868/
https://www.ncbi.nlm.nih.gov/pubmed/27901111
http://dx.doi.org/10.1038/srep38155

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