Wide variation in susceptibility of transmitted/founder HIV-1 subtype C Isolates to protease inhibitors and association with in vitro replication efficiency

The gag gene is highly polymorphic across HIV-1 subtypes and contributes to susceptibility to protease inhibitors (PI), a critical class of antiretrovirals that will be used in up to 2 million individuals as second-line therapy in sub Saharan Africa by 2020. Given subtype C represents around half of...

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Detalles Bibliográficos
Autores principales: Sutherland, Katherine A., Collier, Dami A., Claiborne, Daniel T., Prince, Jessica L., Deymier, Martin J., Goldstein, Richard A., Hunter, Eric, Gupta, Ravindra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128871/
https://www.ncbi.nlm.nih.gov/pubmed/27901085
http://dx.doi.org/10.1038/srep38153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128871/
https://www.ncbi.nlm.nih.gov/pubmed/27901085
http://dx.doi.org/10.1038/srep38153

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