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Analysis of chikungunya virus proteins reveals that non-structural proteins nsP2 and nsP3 exhibit RNA interference (RNAi) suppressor activity

RNAi pathway is an antiviral defence mechanism employed by insects that result in degradation of viral RNA thereby curbing infection. Several viruses including flaviviruses encode viral suppressors of RNAi (VSRs) to counteract the antiviral RNAi pathway. Till date, no VSR has been reported in alphav...

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Detalles Bibliográficos
Autores principales: Mathur, Kalika, Anand, Abhishek, Dubey, Sunil Kumar, Sanan-Mishra, Neeti, Bhatnagar, Raj K., Sunil, Sujatha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128919/
https://www.ncbi.nlm.nih.gov/pubmed/27901124
http://dx.doi.org/10.1038/srep38065