Hypothalamic kappa opioid receptor mediates both diet‐induced and melanin concentrating hormone–induced liver damage through inflammation and endoplasmic reticulum stress

The opioid system is widely known to modulate the brain reward system and thus affect the behavior of humans and other animals, including feeding. We hypothesized that the hypothalamic opioid system might also control energy metabolism in peripheral tissues. Mice lacking the kappa opioid receptor (κ...

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Detalles Bibliográficos
Autores principales: Imbernon, Monica, Sanchez‐Rebordelo, Estrella, Romero‐Picó, Amparo, Kalló, Imre, Chee, Melissa J., Porteiro, Begoña, Al‐Massadi, Omar, Contreras, Cristina, Fernø, Johan, Senra, Ana, Gallego, Rosalia, Folgueira, Cintia, Seoane, Luisa M., van Gestel, Margriet, Adan, Roger A., Liposits, Zsolt, Dieguez, Carlos, López, Miguel, Nogueiras, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Steatohepatitis/Metabolic Liver Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129461/
https://www.ncbi.nlm.nih.gov/pubmed/27387967
http://dx.doi.org/10.1002/hep.28716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129461/
https://www.ncbi.nlm.nih.gov/pubmed/27387967
http://dx.doi.org/10.1002/hep.28716

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