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Hypothalamic kappa opioid receptor mediates both diet‐induced and melanin concentrating hormone–induced liver damage through inflammation and endoplasmic reticulum stress
The opioid system is widely known to modulate the brain reward system and thus affect the behavior of humans and other animals, including feeding. We hypothesized that the hypothalamic opioid system might also control energy metabolism in peripheral tissues. Mice lacking the kappa opioid receptor (κ...
Autores principales: | Imbernon, Monica, Sanchez‐Rebordelo, Estrella, Romero‐Picó, Amparo, Kalló, Imre, Chee, Melissa J., Porteiro, Begoña, Al‐Massadi, Omar, Contreras, Cristina, Fernø, Johan, Senra, Ana, Gallego, Rosalia, Folgueira, Cintia, Seoane, Luisa M., van Gestel, Margriet, Adan, Roger A., Liposits, Zsolt, Dieguez, Carlos, López, Miguel, Nogueiras, Ruben |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129461/ https://www.ncbi.nlm.nih.gov/pubmed/27387967 http://dx.doi.org/10.1002/hep.28716 |
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