In Vitro Functional Analyses of Infrequent Nucleotide Variants in the Lactase Enhancer Reveal Different Molecular Routes to Increased Lactase Promoter Activity and Lactase Persistence

The genetic trait that allows intestinal lactase to persist into adulthood in some 35% of humans worldwide operates at the level of transcription, the effect being caused by cis‐acting nucleotide changes upstream of the lactase gene (LCT). A single nucleotide substitution, ‐13910 C>T, the first c...

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Detalles Bibliográficos
Autores principales: Liebert, Anke, Jones, Bryony L., Danielsen, Erik Thomas, Olsen, Anders Krüger, Swallow, Dallas M., Troelsen, Jesper T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129500/
https://www.ncbi.nlm.nih.gov/pubmed/27714771
http://dx.doi.org/10.1111/ahg.12167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129500/
https://www.ncbi.nlm.nih.gov/pubmed/27714771
http://dx.doi.org/10.1111/ahg.12167

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