Robust anti‐obesity and metabolic effects of a dual GLP‐1/glucagon receptor peptide agonist in rodents and non‐human primates

AIMS: To characterize the pharmacology of MEDI0382, a peptide dual agonist of glucagon‐like peptide‐1 (GLP‐1) and glucagon receptors. MATERIALS AND METHODS: MEDI0382 was evaluated in vitro for its ability to stimulate cAMP accumulation in cell lines expressing transfected recombinant or endogenous G...

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Detalles Bibliográficos
Autores principales: Henderson, S. J., Konkar, A., Hornigold, D. C., Trevaskis, J. L., Jackson, R., Fritsch Fredin, M., Jansson‐Löfmark, R., Naylor, J., Rossi, A., Bednarek, M. A., Bhagroo, N., Salari, H., Will, S., Oldham, S., Hansen, G., Feigh, M., Klein, T., Grimsby, J., Maguire, S., Jermutus, L., Rondinone, C. M., Coghlan, M. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129521/
https://www.ncbi.nlm.nih.gov/pubmed/27377054
http://dx.doi.org/10.1111/dom.12735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129521/
https://www.ncbi.nlm.nih.gov/pubmed/27377054
http://dx.doi.org/10.1111/dom.12735

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