Elimination of proliferating cells from CNS grafts using a Ki67 promoter-driven thymidine kinase

Pluripotent stem cell (PSC)-based cell therapy is an attractive concept for neurodegenerative diseases, but can lead to tumor formation. This is particularly relevant as proliferating neural precursors rather than postmitotic mature neurons need to be transplanted. Thus, safety mechanisms to elimina...

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Detalles Bibliográficos
Autores principales: Tieng, Vannary, Cherpin, Ophelie, Gutzwiller, Eveline, Zambon, Alexander C, Delgado, Christophe, Salmon, Patrick, Dubois-Dauphin, Michel, Krause, Karl-Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129875/
https://www.ncbi.nlm.nih.gov/pubmed/27990449
http://dx.doi.org/10.1038/mtm.2016.69

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129875/
https://www.ncbi.nlm.nih.gov/pubmed/27990449
http://dx.doi.org/10.1038/mtm.2016.69

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