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Elimination of proliferating cells from CNS grafts using a Ki67 promoter-driven thymidine kinase
Pluripotent stem cell (PSC)-based cell therapy is an attractive concept for neurodegenerative diseases, but can lead to tumor formation. This is particularly relevant as proliferating neural precursors rather than postmitotic mature neurons need to be transplanted. Thus, safety mechanisms to elimina...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129875/ https://www.ncbi.nlm.nih.gov/pubmed/27990449 http://dx.doi.org/10.1038/mtm.2016.69 |