MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)(n) or (CTG)(n) hairpins for error-prone DNA synthesis

Expansion of (CAG)•(CTG) repeats causes a number of familial neurodegenerative disorders. Although the underlying mechanism remains largely unknown, components involved in DNA mismatch repair, particularly mismatch recognition protein MutSβ (a MSH2-MSH3 heterodimer), are implicated in (CAG)•(CTG) re...

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Detalles Bibliográficos
Autores principales: Guo, Jinzhen, Gu, Liya, Leffak, Michael, Li, Guo-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129881/
https://www.ncbi.nlm.nih.gov/pubmed/27255792
http://dx.doi.org/10.1038/cr.2016.66

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129881/
https://www.ncbi.nlm.nih.gov/pubmed/27255792
http://dx.doi.org/10.1038/cr.2016.66

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