Cargando…

De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas

About 20% hepatocellular carcinomas (HCCs) display wild-type β-catenin, enhanced Wnt signaling, hepatocyte dedifferentiation and bad outcome, suggesting a specific impact of Wnt signals on HCC stem/progenitor cells. To study Wnt-specific molecular pathways, cell fates and clinical outcome, we fine-t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mebarki, Sihem, Désert, Romain, Sulpice, Laurent, Sicard, Marie, Desille, Mireille, Canal, Frédéric, Schneider, Hélène Dubois-Pot, Bergeat, Damien, Turlin, Bruno, Bellaud, Pascale, Lavergne, Elise, Guével, Rémy Le, Corlu, Anne, Perret, Christine, Coulouarn, Cédric, Clément, Bruno, Musso, Orlando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129911/ https://www.ncbi.nlm.nih.gov/pubmed/27191501 http://dx.doi.org/10.18632/oncotarget.9346

Ejemplares similares

Gene expression profiling of the tumor microenvironment in human intrahepatic cholangiocarcinoma
por: Sulpice, Laurent, et al.
Publicado: (2016)

A novel transforming growth factor beta‐induced long noncoding RNA promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma
por: Merdrignac, Aude, et al.
Publicado: (2018)

Well-differentiated liver cancers reveal the potential link between ACE2 dysfunction and metabolic breakdown
por: Desquilles, Lise, et al.
Publicado: (2022)

Molecular profiling of stroma highlights stratifin as a novel biomarker of poor prognosis in pancreatic ductal adenocarcinoma
por: Robin, Fabien, et al.
Publicado: (2020)

HAPLN1 potentiates peritoneal metastasis in pancreatic cancer
por: Wiedmann, Lena, et al.
Publicado: (2023)

Hapln2 in Neurological Diseases and Its Potential as Therapeutic Target
por: Wang, Qinqin, et al.
Publicado: (2019)

Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion
por: Chen, Yong, et al.
Publicado: (2020)

Key Fibrogenic Signaling
por: He, Weichun, et al.
Publicado: (2015)

HAPLN1 confers multiple myeloma cell resistance to several classes of therapeutic drugs
por: Huynh, Mailee, et al.
Publicado: (2022)

hapln1a(+) cells guide coronary growth during heart morphogenesis and regeneration
por: Sun, Jisheng, et al.
Publicado: (2023)

Inflammation Writes the Fibrogenic Code
por: Friedersdorf, Matthew, et al.
Publicado: (2021)

Hapln1a Is Required for Connexin43-Dependent Growth and Patterning in the Regenerating Fin Skeleton
por: Govindan, Jayalakshmi, et al.
Publicado: (2014)

Elevated Hapln2 Expression Contributes to Protein Aggregation and Neurodegeneration in an Animal Model of Parkinson's Disease
por: Wang, Qinqin, et al.
Publicado: (2016)

HAPLN1 Affects Cell Viability and Promotes the Pro-Inflammatory Phenotype of Fibroblast-Like Synoviocytes
por: Chen, Yong, et al.
Publicado: (2022)

Ectopic CH60 mediates HAPLN1-induced cell survival signaling in multiple myeloma
por: De Bakshi, Debayan, et al.
Publicado: (2022)

SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance
por: Yuan, Xiaodong, et al.
Publicado: (2018)

The rs3957357C>T SNP in GSTA1 Is Associated with a Higher Risk of Occurrence of Hepatocellular Carcinoma in European Individuals
por: Akhdar, Hanane, et al.
Publicado: (2016)

HAPLN1 matrikine: a bone marrow homing factor linked to poor outcomes in patients with MM
por: Chang, Hae Yeun, et al.
Publicado: (2023)

TGF-β in developmental and fibrogenic EMTs
por: Lee, Jun Ho, et al.
Publicado: (2022)

Research transparency promotion by surgical journals publishing randomised controlled trials: a survey
por: Lombard, N., et al.
Publicado: (2020)

Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development
por: Derrick, Christopher J, et al.
Publicado: (2021)

Hapln1b, a central organizer of the ECM, modulates kit signaling to control developmental hematopoiesis in zebrafish
por: Mahony, Christopher B., et al.
Publicado: (2021)

FTO modulates fibrogenic responses in obstructive nephropathy
por: Wang, Chao-Yung, et al.
Publicado: (2016)

Inflammatory and Fibrogenic Factors in Proliferative Vitreoretinopathy Development
por: Chaudhary, Rishika, et al.
Publicado: (2020)

Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin–Beck disease and primary osteoarthritis
por: Zheng, Jingjing, et al.
Publicado: (2013)

Cancer-associated fibroblasts-derived HAPLN1 promotes tumour invasion through extracellular matrix remodeling in gastric cancer
por: Zhang, Tiancheng, et al.
Publicado: (2021)

Transcriptome Analysis Reveals MFGE8-HAPLN3 Fusion as a Novel Biomarker in Triple-Negative Breast Cancer
por: Wang, Meng-Yuan, et al.
Publicado: (2021)

Novel Effect of Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) on Hair Follicle Cells Proliferation and Hair Growth
por: Ha, Hae Chan, et al.
Publicado: (2023)

Adding the oxygen carrier M101 to a cold-storage solution could be an alternative to HOPE for liver graft preservation
por: Alix, Pierre, et al.
Publicado: (2020)

In vitro RPM fibrogenic potential assay of welding fumes.
por: Stern, R M, et al.
Publicado: (1983)

Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis
por: Huaux, François, et al.
Publicado: (2013)

NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation
por: Stenke, Emily, et al.
Publicado: (2020)

The fibrogenic process and the unleashing of acute-on-chronic liver failure
por: López-Sánchez, Guillermo Nahúm, et al.
Publicado: (2020)

ASPN Synergizes with HAPLN1 to Inhibit the Osteogenic Differentiation of Bone Marrow Mesenchymal Stromal Cells and Extracellular Matrix Mineralization of Osteoblasts
por: Zhou, Guohui, et al.
Publicado: (2023)

A Novel Role of Hyaluronic Acid and Proteoglycan Link Protein 1 (HAPLN1) in Delaying Vascular Endothelial Cell Senescence
por: Zhou, Dan, et al.
Publicado: (2023)

Hallmarks of cancer and hallmarks of aging
por: Blagosklonny, Mikhail V.
Publicado: (2022)

BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration
por: Ntumba, Kalonji, et al.
Publicado: (2016)

Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration
por: Pajaud, J, et al.
Publicado: (2015)

Morphological investigations of fibrogenic action of Estonian oil shale dust.
por: Küng, V A
Publicado: (1979)

Key fibrogenic mediators: old players. Renin–angiotensin system
por: Macconi, Daniela, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_vjudhohsdcvohg2m8m2fod6ud1