IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans

An age-related decline in cytolytic activity has been described in CD8(+) T cells and we have previously shown that the poor CD8(+) effector T cell responses to influenza A/H3N2 challenge result from a decline in the proportion and function of these cytolytic T lymphocytes (CTL). Here, we describe t...

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Detalles Bibliográficos
Autores principales: Zhou, Xin, Hopkins, Jacob W., Wang, Chongkai, Brahmakshatriya, Vinayak, Swain, Susan L., Kuchel, George A., Haynes, Laura, McElhaney, Janet E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129923/
https://www.ncbi.nlm.nih.gov/pubmed/27322555
http://dx.doi.org/10.18632/oncotarget.10047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129923/
https://www.ncbi.nlm.nih.gov/pubmed/27322555
http://dx.doi.org/10.18632/oncotarget.10047

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