Interference with mutagenic aflatoxin B1-induced checkpoints through antagonistic action of ochratoxin A in intestinal cancer cells: a molecular explanation on potential risk of crosstalk between carcinogens

Foodborne aflatoxin B(1) (AFB(1)) and ochratoxin A (OTA) cause genotoxic injury and subsequent tumor formation. As a biomarker of oncogenic stimulation by genotoxic mycotoxins, p53-triggered Mdm2 was assessed in intestinal cancer cells. AFB(1) increased Mdm2 reporter expression in a dose-dependent m...

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Detalles Bibliográficos
Autores principales: Kim, Juil, Park, Seong-Hwan, Do, Kee Hun, Kim, Dongwook, Moon, Yuseok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129958/
https://www.ncbi.nlm.nih.gov/pubmed/27119350
http://dx.doi.org/10.18632/oncotarget.8914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129958/
https://www.ncbi.nlm.nih.gov/pubmed/27119350
http://dx.doi.org/10.18632/oncotarget.8914

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