MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells

A rationally selected combination of small-molecule chemicals can affect cell plasticity and fate, suggesting an open chemistry way to manipulate cells to achieve a specific goal. Here we for the first time demonstrate that a combination of vitamin C (Vc) and PD0325901 can achieve about 90% erasure...

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Detalles Bibliográficos
Autores principales: Li, Cuiping, Liu, Baodong, Zhong, Shangwei, Wang, Hailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129966/
https://www.ncbi.nlm.nih.gov/pubmed/27213595
http://dx.doi.org/10.18632/oncotarget.9452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129966/
https://www.ncbi.nlm.nih.gov/pubmed/27213595
http://dx.doi.org/10.18632/oncotarget.9452

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