Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection

Phosphoinositide-3-kinase (PI3K) is an enzyme group, known to regulate key survival pathways in acute myeloid leukaemia (AML). It generates phosphatidylinositol-3,4,5-triphosphate, which provides a membrane docking site for protein kinaseB activation. PI3K catalytic p110 subunits are divided into 4...

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Detalles Bibliográficos
Autores principales: Pillinger, Genevra, Loughran, Niamh V., Piddock, Rachel E., Shafat, Manar S., Zaitseva, Lyubov, Abdul-Aziz, Amina, Lawes, Matthew J., Bowles, Kristian M., Rushworth, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129970/
https://www.ncbi.nlm.nih.gov/pubmed/27174919
http://dx.doi.org/10.18632/oncotarget.9289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129970/
https://www.ncbi.nlm.nih.gov/pubmed/27174919
http://dx.doi.org/10.18632/oncotarget.9289

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