Cargando…

Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance

Lysine demethylase 5A (KDM5A/RBP2/JARID1A) is a histone lysine demethylase that is overexpressed in several human cancers including lung, gastric, breast and liver cancers. It plays key roles in important cancer processes including tumorigenesis, metastasis, and drug tolerance, making it a potential...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gale, Molly, Sayegh, Joyce, Cao, Jian, Norcia, Michael, Gareiss, Peter, Hoyer, Denton, Merkel, Jane S., Yan, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129982/ https://www.ncbi.nlm.nih.gov/pubmed/27224921 http://dx.doi.org/10.18632/oncotarget.9539

Ejemplares similares

Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer
por: Blair, Lauren P., et al.
Publicado: (2011)

Machine-Learning-Enabled Virtual Screening for Inhibitors of Lysine-Specific Histone Demethylase 1
por: Zhou, Jiajun, et al.
Publicado: (2021)

Chemical Biology of Lysine Demethylases
por: Heightman, Tom D
Publicado: (2011)

Histone demethylase lysine demethylase 5B in development and cancer
por: Han, Mengjiao, et al.
Publicado: (2016)

Histone lysine demethylases in Drosophila melanogaster
por: Holowatyj, Andreana, et al.
Publicado: (2015)

Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases
por: Niwa, Hideaki, et al.
Publicado: (2017)

A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay
por: Wu, Qiong, et al.
Publicado: (2021)

Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1
por: Zhou, Chao, et al.
Publicado: (2017)

The role of histone lysine demethylases in cancer cells’ resistance to tyrosine kinase inhibitors
por: White, Jasmine Cassar, et al.
Publicado: (2019)

Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery
por: Das, Nando Dulal, et al.
Publicado: (2023)

Histone lysine demethylases in mammalian embryonic development
por: Shen, Hongjie, et al.
Publicado: (2017)

Discovery of a Highly Selective Cell‐Active Inhibitor of the Histone Lysine Demethylases KDM2/7
por: Gerken, Philip A., et al.
Publicado: (2017)

Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors
por: Shi, Ying, et al.
Publicado: (2018)

KDM5 lysine demethylases are involved in maintenance of 3′UTR length
por: Blair, Lauren P., et al.
Publicado: (2016)

The emerging role of histone lysine demethylases in prostate cancer
por: Crea, Francesco, et al.
Publicado: (2012)

Androgen Receptor and Histone Lysine Demethylases in Ovine Placenta
por: Cleys, Ellane R., et al.
Publicado: (2015)

Targeting histone lysine demethylases — Progress, challenges, and the future()
por: Thinnes, Cyrille C., et al.
Publicado: (2014)

Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity
por: Suzuki, Takayoshi, et al.
Publicado: (2013)

Synthetic Studies toward the Natural Product Tripartin, the First Natural Histone Lysine Demethylase Inhibitor
por: Dethe, Dattatraya H., et al.
Publicado: (2018)

Discovery of orally active chalcones as histone lysine specific demethylase 1 inhibitors for the treatment of leukaemia
por: Li, Yang, et al.
Publicado: (2020)

The Lysine Demethylase KDM7A Regulates Immediate Early Genes in Neurons
por: Wang, Yifan, et al.
Publicado: (2023)

Reader domain specificity and lysine demethylase-4 family function
por: Su, Zhangli, et al.
Publicado: (2016)

Prominent role of histone lysine demethylases in cancer epigenetics and therapy
por: Janardhan, Avilala, et al.
Publicado: (2018)

Lysine Demethylases: Promising Drug Targets in Melanoma and Other Cancers
por: Punnia-Moorthy, Gaya, et al.
Publicado: (2021)

Possible Role of Lysine Demethylase 2A in the Pathophysiology of Psoriasis
por: Kim, Dong Ha, et al.
Publicado: (2020)

Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean
por: Liu, Mengshi, et al.
Publicado: (2022)

Selective lysine‐specific demethylase 1 inhibitor, NCL1, could cause testicular toxicity via the regulation of apoptosis
por: Nozaki, Satoshi, et al.
Publicado: (2020)

Oocyte-Specific Knockout of Histone Lysine Demethylase KDM2a Compromises Fertility by Blocking the Development of Follicles and Oocytes
por: Xiong, Xianrong, et al.
Publicado: (2022)

VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases
por: Ekstrom, Thomas L., et al.
Publicado: (2021)

Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles
por: Stitzlein, Lea M., et al.
Publicado: (2023)

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors
por: King, Oliver N. F., et al.
Publicado: (2010)

Novel Scaffolds of Cell-Active Histone Demethylase Inhibitors Identified from High-Throughput Screening
por: Wang, Wei, et al.
Publicado: (2015)

NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect
por: Etani, Toshiki, et al.
Publicado: (2014)

Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer
por: Chen, Cong, et al.
Publicado: (2015)

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer
por: Majello, Barbara, et al.
Publicado: (2019)

Inhibition of FAD-dependent lysine-specific demethylases by chiral polyamine analogues
por: Umezawa, Naoki, et al.
Publicado: (2018)

Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases
por: Kim, Dongha, et al.
Publicado: (2021)

Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics
por: Chianese, Ugo, et al.
Publicado: (2022)

Epigenetic Control of Muscle Stem Cells: Focus on Histone Lysine Demethylases
por: Cicciarello, Delia, et al.
Publicado: (2022)

Mechanisms of carcinogenic activity triggered by lysine-specific demethylase 1A
por: Yang, Chao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_df4aftvdlsafrsmb7j385kqj7b