Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN gene

Phosphatase and tensin homolog (PTEN) is a major tumor suppressor and usually silenced via the deletion, insertion and mutation. We previously discovered its inactivation via aberrant CpG island methylation. Here, we provide further evidence that EBV latent membrane protein 1(LMP1) can induce a high...

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Detalles Bibliográficos
Autores principales: Peng, Hong, Chen, Yuxiang, Gong, Pinggui, Cai, Longmei, Lyu, Xiaoming, Jiang, Qiang, Wang, Jianguo, Lu, Juan, Yao, Kaitai, Liu, Kunping, Li, Jinbang, Li, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129989/
https://www.ncbi.nlm.nih.gov/pubmed/27223069
http://dx.doi.org/10.18632/oncotarget.9474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129989/
https://www.ncbi.nlm.nih.gov/pubmed/27223069
http://dx.doi.org/10.18632/oncotarget.9474

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