Isoliensinine induces dephosphorylation of NF-κB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction

Our previous study discovered that isoliensinine (isolie) triggers hepatocellular carcinoma (HCC) cell apoptosis via inducing p65 dephosphorylation at Ser536 and inhibition of NF-κB. Here, we showed that isolie promoted p65/PP2A interaction in vitro and in vivo. Repression of PP2A activity or knockd...

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Detalles Bibliográficos
Autores principales: Shu, Guangwen, Zhang, Lang, Jiang, Shanqing, Cheng, Zhuo, Wang, Guan, Huang, Xu, Yang, Xinzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130008/
https://www.ncbi.nlm.nih.gov/pubmed/27244888
http://dx.doi.org/10.18632/oncotarget.9603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130008/
https://www.ncbi.nlm.nih.gov/pubmed/27244888
http://dx.doi.org/10.18632/oncotarget.9603

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