Cargando…

Heads, Shoulders, Elbows, Knees, and Toes: Modular Gdf5 Enhancers Control Different Joints in the Vertebrate Skeleton

Synovial joints are crucial for support and locomotion in vertebrates, and are the frequent site of serious skeletal defects and degenerative diseases in humans. Growth and differentiation factor 5 (Gdf5) is one of the earliest markers of joint formation, is required for normal joint development in...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Hao, Capellini, Terence D., Schoor, Michael, Mortlock, Doug P., Reddi, A. Hari, Kingsley, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130176/
https://www.ncbi.nlm.nih.gov/pubmed/27902701
http://dx.doi.org/10.1371/journal.pgen.1006454