Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

The capsid structural protein of the New World alphavirus, Venezuelan equine encephalitis virus (VEEV), interacts with the host nuclear transport proteins importin α/β1 and CRM1. Novel selective inhibitor of nuclear export (SINE) compounds, KPT-185, KPT-335 (verdinexor), and KPT-350, target the host...

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Detalles Bibliográficos
Autores principales: Lundberg, Lindsay, Pinkham, Chelsea, de la Fuente, Cynthia, Brahms, Ashwini, Shafagati, Nazly, Wagstaff, Kylie M., Jans, David A., Tamir, Sharon, Kehn-Hall, Kylene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130180/
https://www.ncbi.nlm.nih.gov/pubmed/27902702
http://dx.doi.org/10.1371/journal.pntd.0005122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130180/
https://www.ncbi.nlm.nih.gov/pubmed/27902702
http://dx.doi.org/10.1371/journal.pntd.0005122

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