Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson’s Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque

Recent failures in clinical trials for disease modification in Parkinson’s disease have highlighted the need for a non-human primate model of the synucleinopathy underpinning dopaminergic neuron degeneration. The present study was defined to begin the development of such a model in cynomolgus macaqu...

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Detalles Bibliográficos
Autores principales: Koprich, James B., Johnston, Tom H., Reyes, Gabriela, Omana, Vanessa, Brotchie, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130249/
https://www.ncbi.nlm.nih.gov/pubmed/27902767
http://dx.doi.org/10.1371/journal.pone.0167235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130249/
https://www.ncbi.nlm.nih.gov/pubmed/27902767
http://dx.doi.org/10.1371/journal.pone.0167235

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