Cargando…

Determinants of tRNA Recognition by the Radical SAM Enzyme RlmN

RlmN, a bacterial radical SAM methylating enzyme, has the unusual ability to modify two distinct types of RNA: 23S rRNA and tRNA. In rRNA, RlmN installs a methyl group at the C2 position of A2503 of 23S rRNA, while in tRNA the modification occurs at nucleotide A37, immediately adjacent to the antico...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fitzsimmons, Christina M., Fujimori, Danica Galonić
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130265/ https://www.ncbi.nlm.nih.gov/pubmed/27902775 http://dx.doi.org/10.1371/journal.pone.0167298

Ejemplares similares

Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii
por: Padgett, Leah R., et al.
Publicado: (2018)

Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases
por: Ntokou, Eleni, et al.
Publicado: (2015)

Characterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmN
por: Silakov, Alexey, et al.
Publicado: (2014)

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme
por: Stojković, Vanja, et al.
Publicado: (2016)

Mechanistic and functional versatility of radical SAM enzymes
por: Booker, Squire J, et al.
Publicado: (2010)

Paramagnetic Intermediates Generated by Radical S-Adenosylmethionine (SAM) Enzymes
por: Stich, Troy A., et al.
Publicado: (2014)

Carbon extension in peptidylnucleoside biosynthesis by radical-SAM enzymes
por: Lilla, Edward A., et al.
Publicado: (2016)

Salvage of the 5-deoxyribose byproduct of radical SAM enzymes
por: Beaudoin, Guillaume A. W., et al.
Publicado: (2018)

The vulnerability of radical SAM enzymes to oxidants and soft metals
por: Rohaun, Sanjay Kumar, et al.
Publicado: (2022)

Radical SAM Enzymes Involved in Tetrapyrrole Biosynthesis and Insertion
por: Layer, Gunhild, et al.
Publicado: (2022)

Brassica napus genes Rlm4 and Rlm7, conferring resistance to Leptosphaeria maculans, are alleles of the Rlm9 wall‐associated kinase‐like resistance locus
por: Haddadi, Parham, et al.
Publicado: (2022)

RadicalSAM.org: A Resource to Interpret Sequence-Function Space and Discover New Radical SAM Enzyme Chemistry
por: Oberg, Nils, et al.
Publicado: (2021)

Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations
por: Ugur, Fatima S., et al.
Publicado: (2023)

Chemical tools targeting readers of lysine methylation
por: Ortiz, Gloria, et al.
Publicado: (2023)

Evolution of Methods for the Study of Cobalamin-Dependent Radical SAM Enzymes
por: Sinner, Erica K., et al.
Publicado: (2021)

Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme
por: Benjdia, Alhosna, et al.
Publicado: (2012)

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme
por: Shisler, Krista A., et al.
Publicado: (2017)

Radical SAM Enzymes and Metallocofactor Assembly: A Structural Point of View
por: Nicolet, Yvain, et al.
Publicado: (2021)

Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD
por: Jiang, Yiyang, et al.
Publicado: (2017)

Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3
por: Wong, Cintyu, et al.
Publicado: (2009)

tRNA recognition by a bacterial tRNA Xm32 modification enzyme from the SPOUT methyltransferase superfamily
por: Liu, Ru-Juan, et al.
Publicado: (2015)

Characterizing SPASM/twitch Domain-Containing Radical SAM Enzymes by EPR Spectroscopy
por: Balo, Aidin R., et al.
Publicado: (2021)

Evidence for Porphyrin-Mediated Electron Transfer in the Radical SAM Enzyme HutW
por: Brimberry, Marley, et al.
Publicado: (2023)

Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD
por: Jiang, Yiyang, et al.
Publicado: (2018)

Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance
por: Tsai, Kaitlyn, et al.
Publicado: (2022)

A SAM-I riboswitch with the ability to sense and respond to uncharged initiator tRNA
por: Tang, Dong-Jie, et al.
Publicado: (2020)

A B(12)-dependent radical SAM enzyme involved in Oxetanocin-A biosynthesis
por: Bridwell-Rabb, Jennifer, et al.
Publicado: (2017)

Intermolecular electron transfer in radical SAM enzymes as a new paradigm for reductive activation
por: Eastman, Karsten A.S., et al.
Publicado: (2023)

Recognition of pyrrolysine tRNA by the Desulfitobacterium hafniense pyrrolysyl-tRNA synthetase
por: Herring, Stephanie, et al.
Publicado: (2007)

The structural basis of tRNA recognition by arginyl-tRNA-protein transferase
por: Abeywansha, Thilini, et al.
Publicado: (2023)

Structure-guided discovery of carboxy-SAM as a novel metabolite modulating tRNA function
por: Kim, Jungwook, et al.
Publicado: (2013)

Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)
por: Benjdia, Alhosna, et al.
Publicado: (2017)

Analysis of Electrochemical Properties of S-Adenosyl-l-methionine and Implications for Its Role in Radical SAM Enzymes
por: Miller, Sven A., et al.
Publicado: (2019)

Cluster-selective (57)Fe labeling of a Twitch-domain-containing radical SAM enzyme
por: Namkoong, Gil, et al.
Publicado: (2023)

Impact of tRNA Modifications and tRNA-Modifying Enzymes on Proteostasis and Human Disease
por: Pereira, Marisa, et al.
Publicado: (2018)

Journey on the Radical SAM Road as an Accidental Pilgrim
por: Bandarian, Vahe
Publicado: (2022)

Structure and Catalytic Mechanism of Radical SAM Methylases
por: Nguyen, Tu-Quynh, et al.
Publicado: (2022)

Twenty Years of Radical SAM! The Genesis of the Superfamily
por: Booker, Squire J., et al.
Publicado: (2022)

RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmA(II) in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility
por: Shoji, Tatsuma, et al.
Publicado: (2015)

The tRNA Elbow in Structure, Recognition and Evolution
por: Zhang, Jinwei, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dk4tgqqdpinp46r30qaq692cae