Targeting Mechanotransduction at the Transcriptional Level: YAP and BRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis

Liver fibrosis is the result of a deregulated wound healing process characterized by the excessive deposition of extracellular matrix. Hepatic stellate cells (HSCs), which are activated in response to liver injury, are the major source of extracellular matrix and drive the wound healing process. How...

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Detalles Bibliográficos
Autores principales: Zhubanchaliyev, Altynbek, Temirbekuly, Aibar, Kongrtay, Kuralay, Wanshura, Leah C., Kunz, Jeannette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131002/
https://www.ncbi.nlm.nih.gov/pubmed/27990121
http://dx.doi.org/10.3389/fphar.2016.00462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131002/
https://www.ncbi.nlm.nih.gov/pubmed/27990121
http://dx.doi.org/10.3389/fphar.2016.00462

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