Post-Translational Incorporation of L-Phenylalanine into the C-Terminus of α-Tubulin as a Possible Cause of Neuronal Dysfunction

α-Tubulin C-terminus undergoes post-translational, cyclic tyrosination/detyrosination, and L-Phenylalanine (Phe) can be incorporated in place of tyrosine. Using cultured mouse brain-derived cells and an antibody specific to Phe-tubulin, we showed that: (i) Phe incorporation into tubulin is reversibl...

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Detalles Bibliográficos
Autores principales: Ditamo, Yanina, Dentesano, Yanela M., Purro, Silvia A., Arce, Carlos A., Bisig, C. Gastón
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131269/
https://www.ncbi.nlm.nih.gov/pubmed/27905536
http://dx.doi.org/10.1038/srep38140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131269/
https://www.ncbi.nlm.nih.gov/pubmed/27905536
http://dx.doi.org/10.1038/srep38140

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