Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate

Kv7.2 and Kv7.3 subunits underlie the M-current, a neuronal K(+) current characterized by an absolute functional requirement for phosphatidylinositol 4,5-bisphosphate (PIP(2)). Kv7.2 gene mutations cause early-onset neonatal seizures with heterogeneous clinical outcomes, ranging from self-limiting b...

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Detalles Bibliográficos
Autores principales: Soldovieri, Maria Virginia, Ambrosino, Paolo, Mosca, Ilaria, De Maria, Michela, Moretto, Edoardo, Miceli, Francesco, Alaimo, Alessandro, Iraci, Nunzio, Manocchio, Laura, Medoro, Alessandro, Passafaro, Maria, Taglialatela, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131271/
https://www.ncbi.nlm.nih.gov/pubmed/27905566
http://dx.doi.org/10.1038/srep38167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131271/
https://www.ncbi.nlm.nih.gov/pubmed/27905566
http://dx.doi.org/10.1038/srep38167

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