Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates

The ability to revitalize and re-purpose existing drugs offers a powerful approach for novel treatment options against Mycobacterium tuberculosis and other infectious agents. Antifolates are an underutilized drug class in tuberculosis (TB) therapy, capable of disrupting the biosynthesis of tetrahydr...

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Detalles Bibliográficos
Autores principales: Thiede, Joshua M., Kordus, Shannon L., Turman, Breanna J., Buonomo, Joseph A., Aldrich, Courtney C., Minato, Yusuke, Baughn, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131483/
https://www.ncbi.nlm.nih.gov/pubmed/27905500
http://dx.doi.org/10.1038/srep38083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131483/
https://www.ncbi.nlm.nih.gov/pubmed/27905500
http://dx.doi.org/10.1038/srep38083

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