TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infection of monocytes

BACKGROUND: Monocytes, the primary myeloid cell-type in peripheral blood, are resistant to HIV-1 infection as a result of the lentiviral restriction factor SAMHD1. Toll-like receptors recognize microbial pathogen components, inducing the expression of antiviral host proteins and proinflammatory cyto...

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Detalles Bibliográficos
Autores principales: Hofmann, Henning, Vanwalscappel, Bénédicte, Bloch, Nicolin, Landau, Nathaniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131500/
https://www.ncbi.nlm.nih.gov/pubmed/27905985
http://dx.doi.org/10.1186/s12977-016-0316-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131500/
https://www.ncbi.nlm.nih.gov/pubmed/27905985
http://dx.doi.org/10.1186/s12977-016-0316-3

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