The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels

Dexmedetomidine (DEX) may act as an antioxidant through regulation of TRPM2 and TRPV1 channel activations in the neurons by reducing cerebral ischemia-induced oxidative stress and apoptosis. The neuroprotective roles of DEX were tested on cerebral ischemia (ISC) in the cultures of rat primary hippoc...

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Detalles Bibliográficos
Autores principales: Akpınar, Hatice, Nazıroğlu, Mustafa, Övey, İshak Suat, Çiğ, Bilal, Akpınar, Orhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131653/
https://www.ncbi.nlm.nih.gov/pubmed/27872485
http://dx.doi.org/10.1038/srep37196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131653/
https://www.ncbi.nlm.nih.gov/pubmed/27872485
http://dx.doi.org/10.1038/srep37196

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