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Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5

Assembly of the spliceosomal small nuclear ribonucleoparticle (snRNP) core requires the participation of the multisubunit SMN (survival of motor neuron) complex, which contains SMN and several Gemin proteins. The SMN and Gemin2 subunits directly bind Sm proteins, and Gemin5 is required for snRNP bio...

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Detalles Bibliográficos
Autores principales: Jin, Wenxing, Wang, Yi, Liu, Chao-Pei, Yang, Na, Jin, Mingliang, Cong, Yao, Wang, Mingzhu, Xu, Rui-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131779/
https://www.ncbi.nlm.nih.gov/pubmed/27881601
http://dx.doi.org/10.1101/gad.291377.116