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Model‐Based Assessment of Alternative Study Designs in Pediatric Trials. Part I: Frequentist Approaches
Alternative designs can increase the feasibility of pediatric trials when compared to classical parallel designs (PaD). In this work we present a model‐based approach based on clinical trial simulations for the comparison of PaD with the alternative sequential, crossover, and randomized withdrawal (...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131885/ https://www.ncbi.nlm.nih.gov/pubmed/27300083 http://dx.doi.org/10.1002/psp4.12083 |