Cargando…

Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging

The majority of cilia are formed and maintained by the highly conserved process of intraflagellar transport (IFT). Mutations in IFT genes lead to ciliary structural defects and systemic disorders termed ciliopathies. Here we show that the severely truncated sensory cilia of hypomorphic IFT mutants i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cornils, Astrid, Maurya, Ashish K., Tereshko, Lauren, Kennedy, Julie, Brear, Andrea G., Prahlad, Veena, Blacque, Oliver E., Sengupta, Piali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131903/ https://www.ncbi.nlm.nih.gov/pubmed/27906968 http://dx.doi.org/10.1371/journal.pgen.1006325

Ejemplares similares

The DYF-5 RCK and CDKL-1 CDKL5 kinases contribute differentially to shape distinct sensory neuron cilia morphologies in C. elegans
por: Maurya, Ashish Kumar, et al.
Publicado: (2022)

The Retrograde IFT Machinery of C. elegans Cilia: Two IFT Dynein Complexes?
por: Hao, Limin, et al.
Publicado: (2011)

Cilia and sensory signaling: The journey from “animalcules” to human disease
por: Sengupta, Piali
Publicado: (2017)

A high-resolution morphological and ultrastructural map of anterior sensory cilia and glia in Caenorhabditis elegans
por: Doroquez, David B, et al.
Publicado: (2014)

Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors
por: Pan, Xiaoyu, et al.
Publicado: (2006)

Ensemble and single-molecule dynamics of IFT dynein in Caenorhabditis elegans cilia
por: Mijalkovic, Jona, et al.
Publicado: (2017)

The IFT20 homolog in Caenorhabditis elegans is required for ciliogenesis and cilia-mediated behavior
por: De-Castro, Ana R. G., et al.
Publicado: (2021)

The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition
por: DiTirro, Danielle, et al.
Publicado: (2019)

The BBSome controls IFT assembly and turnaround in cilia
por: Wei, Qing, et al.
Publicado: (2012)

Primary cilia-associated protein IFT172 in ciliopathies
por: Zheng, Nan-Xi, et al.
Publicado: (2023)

Intraflagellar transport 46 (IFT46) is essential for trafficking IFT proteins between cilia and cytoplasm in Paramecium
por: Shi, Lei, et al.
Publicado: (2018)

The cilia protein IFT88 is required for spindle orientation in mitosis
por: Delaval, Benedicte, et al.
Publicado: (2011)

Role of a Class Dhc1b Dynein in Retrograde Transport of Ift Motors and Ift Raft Particles along Cilia, but Not Dendrites, in Chemosensory Neurons of Living Caenorhabditis elegans
por: Signor, Dawn, et al.
Publicado: (1999)

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans
por: Evans, James E., et al.
Publicado: (2006)

Chlamydomonas Kinesin-II–dependent Intraflagellar Transport (IFT): IFT Particles Contain Proteins Required for Ciliary Assembly in Caenorhabditis elegans Sensory Neurons
por: Cole, Douglas G., et al.
Publicado: (1998)

A Cilia Independent Role of Ift88/Polaris during Cell Migration
por: Boehlke, Christopher, et al.
Publicado: (2015)

Cilia-associated wound repair mediated by IFT88 in retinal pigment epithelium
por: Ning, Ke, et al.
Publicado: (2023)

The retrograde IFT dynein is required for normal function of diverse mechanosensory cilia in Drosophila
por: Sharma, Yashoda, et al.
Publicado: (2023)

Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome
por: Duran, Ivan, et al.
Publicado: (2016)

A screen for mutants with abnormal cilia number in C. elegans
por: Adachi, T
Publicado: (2012)

Distinct Activities of Gli1 and Gli2 in the Absence of Ift88 and the Primary Cilia
por: Wang, Yuan, et al.
Publicado: (2019)

Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development
por: Pruski, Michal, et al.
Publicado: (2019)

Requirement of IFT-B–BBSome complex interaction in export of GPR161 from cilia
por: Nozaki, Shohei, et al.
Publicado: (2019)

IFT74 variants cause skeletal ciliopathy and motile cilia defects in mice and humans
por: Bakey, Zeineb, et al.
Publicado: (2023)

See[ing] elegance in sensory biology: an interview with Piali Sengupta
por: Sengupta, Piali
Publicado: (2023)

The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
por: Liem, Karel F., et al.
Publicado: (2012)

Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation
por: Paulson, Delayna, et al.
Publicado: (2021)

The rise and fall of basal bodies in the nematode Caenorhabditis elegans
por: Nechipurenko, Inna V., et al.
Publicado: (2017)

Investigation of a novel cilia-related gene K04F10.2/KIAA0556 in C. elegans
por: Sanders, A, et al.
Publicado: (2012)

Robust interaction of IFT70 with IFT52–IFT88 in the IFT-B complex is required for ciliogenesis
por: Takei, Ryota, et al.
Publicado: (2018)

Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons
por: Tereshko, Lauren, et al.
Publicado: (2021)

Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1–mediated endocytosis
por: Coveney, Clarissa R., et al.
Publicado: (2018)

WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing
por: De-Castro, Ana R.G., et al.
Publicado: (2021)

How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli
por: Goodman, Miriam B., et al.
Publicado: (2019)

The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans
por: Niwa, Shinsuke
Publicado: (2016)

Chemosensory signal transduction in Caenorhabditis elegans
por: Ferkey, Denise M, et al.
Publicado: (2021)

Environmental responsiveness of tubulin glutamylation in sensory cilia is regulated by the p38 MAPK pathway
por: Kimura, Yoshishige, et al.
Publicado: (2018)

Intraflagellar Transport (IFT) Protein IFT25 Is a Phosphoprotein Component of IFT Complex B and Physically Interacts with IFT27 in Chlamydomonas
por: Wang, Zhaohui, et al.
Publicado: (2009)

DGKδ triggers endoplasmic reticulum release of IFT88-containing vesicles destined for the assembly of primary cilia
por: Ding, Jie, et al.
Publicado: (2017)

Corrigendum to: Chemosensory signal transduction in Caenorhabditis elegans
por: Ferkey, Denise M, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_31poa0qgt9dp9pso6h5kvoslpi