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ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites
Nucleosides represent a major chemotherapeutic class for treating cancer, however their limitations in terms of cellular uptake, nucleoside kinase-mediated activation and catabolism are well-documented. The monophosphate pro-nucleotides known as ProTides represents a powerful strategy for bypassing...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131913/ https://www.ncbi.nlm.nih.gov/pubmed/27818111 http://dx.doi.org/10.1016/j.bmcl.2016.10.077 |