ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites

Nucleosides represent a major chemotherapeutic class for treating cancer, however their limitations in terms of cellular uptake, nucleoside kinase-mediated activation and catabolism are well-documented. The monophosphate pro-nucleotides known as ProTides represents a powerful strategy for bypassing...

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Detalles Bibliográficos
Autores principales: Kandil, Sahar, Balzarini, Jan, Rat, Stephanie, Brancale, Andrea, Westwell, Andrew D., McGuigan, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131913/
https://www.ncbi.nlm.nih.gov/pubmed/27818111
http://dx.doi.org/10.1016/j.bmcl.2016.10.077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131913/
https://www.ncbi.nlm.nih.gov/pubmed/27818111
http://dx.doi.org/10.1016/j.bmcl.2016.10.077

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