Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides

We report the synthesis of a series of novel 2′-deoxy-2′,2′-difluoro-5-halouridines and their corresponding phosphoramidate ProTides. All compounds were evaluated for antiviral activity and for cellular toxicity. Interestingly, 2′-deoxy-2′,2′-difluoro-5-iodo- and -5-bromo-uridines showed selective a...

Descripción completa

Detalles Bibliográficos
Autores principales: Quintiliani, Maurizio, Persoons, Leentje, Solaroli, Nicola, Karlsson, Anna, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, McGuigan, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127735/
https://www.ncbi.nlm.nih.gov/pubmed/21696963
http://dx.doi.org/10.1016/j.bmc.2011.05.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127735/
https://www.ncbi.nlm.nih.gov/pubmed/21696963
http://dx.doi.org/10.1016/j.bmc.2011.05.037

Ejemplares similares