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Microwave-assisted organic synthesis of nucleoside ProTide analogues

A microwave enhanced synthesis of prodrug nucleotide (ProTide) analogues is presented. Comparison of conventional thermal heating reaction with microwave irradiation exemplifies the potential of the novel methodology herein presented for the selective 5′-phosphoramidate synthesis, without protection...

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Detalles Bibliográficos
Autores principales: Bordoni, Cinzia, Cima, Cecilia Maria, Azzali, Elisa, Costantino, Gabriele, Brancale, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9065484/
https://www.ncbi.nlm.nih.gov/pubmed/35514718
http://dx.doi.org/10.1039/c9ra01754b