Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin

Ribavirin is a nucleoside analogue with broad antiviral activity. Here we report the synthesis and biological evaluation of novel ribavirin ProTides designed to deliver the bioactive ribavirin monophosphate into cells. Some of the compounds display activity similar to the parent nucleoside against a...

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Detalles Bibliográficos
Autores principales: Derudas, Marco, Brancale, Andrea, Naesens, Lieve, Neyts, Johan, Balzarini, Jan, McGuigan, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125978/
https://www.ncbi.nlm.nih.gov/pubmed/20207546
http://dx.doi.org/10.1016/j.bmc.2010.02.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125978/
https://www.ncbi.nlm.nih.gov/pubmed/20207546
http://dx.doi.org/10.1016/j.bmc.2010.02.015

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