Real-Time Fluorescence Measurements of ROS and [Ca(2+)] in Ischemic / Reperfused Rat Hearts: Detectable Increases Occur only after Mitochondrial Pore Opening and Are Attenuated by Ischemic Preconditioning

Mitochondrial permeability transition pore (mPTP) opening is critical for ischemia / reperfusion (I/R) injury and is associated with increased [Ca(2+)] and reactive oxygen species (ROS). Here we employ surface fluorescence to establish the temporal sequence of these events in beating perfused hearts...

Descripción completa

Detalles Bibliográficos
Autores principales: Andrienko, Tatyana, Pasdois, Philippe, Rossbach, Andreas, Halestrap, Andrew P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131916/
https://www.ncbi.nlm.nih.gov/pubmed/27907091
http://dx.doi.org/10.1371/journal.pone.0167300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131916/
https://www.ncbi.nlm.nih.gov/pubmed/27907091
http://dx.doi.org/10.1371/journal.pone.0167300

Ejemplares similares