Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome

Compelling evidence suggests that defective DNA damage response (DDR) plays a key role in the premature aging phenotypes in Hutchinson-Gilford progeria syndrome (HGPS). Studies document widespread alterations in histone modifications in HGPS cells, especially, the global loss of histone H3 trimethyl...

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Detalles Bibliográficos
Autores principales: Zhang, Haoyue, Sun, Linlin, Wang, Kun, Wu, Di, Trappio, Mason, Witting, Celeste, Cao, Kan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131972/
https://www.ncbi.nlm.nih.gov/pubmed/27907109
http://dx.doi.org/10.1371/journal.pone.0167454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131972/
https://www.ncbi.nlm.nih.gov/pubmed/27907109
http://dx.doi.org/10.1371/journal.pone.0167454

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